Design, synthesis and antibacterial evaluation of novel 1, 2, 3-triazole derivatives incorporating 3'-deoxythymidine. (1st November 2017)

• Record Type: Journal Article
• Authors: Mao, Long-Fei; Xu, Gui-Qing; Sun, Bin; Jiang, Yu-Qin; Dong, Wen-Pei; Zhang, Shu-Ting; Shen, Jia-Xuan; He, Xing
• Is Part Of: Journal of chemical research. Volume 41:Number 11(2017)
• Page Start: 645
• Page End: 649
• Publication Date: 2017-11-01
• Subjects: Chemistry -- Research -- Periodicals; Chemistry -- Periodicals; 540.5
• DOI: 10.3184/174751917X15094552081189
• Languages: English
• ISSNs: 1747-5198

Abstract

A series of novel 1, 2, 3-triazole derivatives incorporating 3'-deoxythymidine were designed, synthesised and characterised. Antibacterial activity against Escherichia coli and Staphylococcus aureus was evaluated for all of the synthesised compounds and compared against standard antibiotic drugs, streptomycin sulfate and doxycycline, as controls. Some compounds showed potential antibacterial activity towards E. coli, and the best minimum inhibitory concentration was 0.14 mM. Preliminary structure–activity relationships and computational simulations were also studied.