Association of the GRIN2B rs2284411 polymorphism with methylphenidate response in attention-deficit/hyperactivity disorder. (August 2017)

• Record Type: Journal Article
• Authors: Kim, Johanna I; Kim, Jae-Won; Park, Jong-Eun; Park, Subin; Hong, Soon-Beom; Han, Doug Hyun; Cheong, Jae Hoon; Choi, Jae-Won; Lee, Sumin; Kim, Bung-Nyun
• Is Part Of: Journal of psychopharmacology. Volume 31:Number 8(2017)
• Page Start: 1070
• Page End: 1077
• Publication Date: 2017-08
• Subjects: Attention-deficit/hyperactivity disorder -- glutamate receptors -- methylphenidate -- pharmacogenetics; Psychopharmacology -- Periodicals; 615.78
• DOI: 10.1177/0269881116667707
• Languages: English
• ISSNs: 0269-8811

Abstract

Objective: We investigated the possible association between two NMDA subunit gene polymorphisms (GRIN2B rs2284411 and GRIN2A rs2229193) and treatment response to methylphenidate (MPH) in attention-deficit/hyperactivity disorder (ADHD). Methods: A total of 75 ADHD patients aged 6–17 years underwent 6 months of MPH administration. Treatment response was defined by changes in scores of the ADHD-IV Rating Scale (ADHD-RS), clinician-rated Clinical Global Impression—Improvement (CGI-I), and Continuous Performance Test (CPT). The association of the GRIN2B and GRIN2A polymorphisms with treatment response was analyzed using logistic regression analyses. Results: The GRIN2B rs2284411 C/C genotype showed significantly better treatment response as assessed by ADHD-RS inattention ( p =0.009) and CGI-I scores ( p =0.009), and there was a nominally significant association in regard to ADHD-RS hyperactivity-impulsivity ( p =0.028) and total ( p =0.023) scores, after adjusting for age, sex, IQ, baseline Clinical Global Impression—Severity (CGI-S) score, baseline ADHD-RS total score, and final MPH dose. The GRIN2B C/C genotype also showed greater improvement at the CPT response time variability ( p <0.001). The GRIN2A G/G genotype was associated with a greater improvement in commission errors of the CPT compared to the G/A genotype ( p =0.001). Conclusions: The results suggest that the GRIN2B rs2284411 genotype may be an important predictor of MPH response in ADHD.