Investigation of antimicrobial properties and in‐vitro bioactivity of Ce3+‐Sr2+dual‐substituted nano hydroxyapatites. Issue 1 (5th July 2018)

• Record Type: Journal Article
• Authors: Sundarabharathi, Lakshmanaperumal; Chinnaswamy, Mahendran; Ponnamma, Deepalekshmi; Parangusan, Hemalatha; Al‐Maadeed, Mariam Al Ali
• Is Part Of: Journal of the American Ceramic Society. Volume 102:Issue 1(2019)
• Page Start: 144
• Page End: 157
• Publication Date: 2018-07-05
• Subjects: bioactivity -- biocompatibility -- hydroxyapatite -- live cell imaging -- Sol‐gel; Ceramics -- Periodicals; 620.1405
• DOI: 10.1111/jace.15866
• Languages: English
• ISSNs: 0002-7820

Abstract

Abstract: Dual doped calcium apatite has been widely focused as it enhances the osteoconductive property for the possible applications in orthopedic and dental implants. In this work, we investigate the antimicrobial and bioactive properties of cerium/strontium (Ce 3+ /Sr 2+ ) co‐substituted hydroxyapatite (HA) nanoparticles synthesized by sol‐gel assisted precipitation method. The structure, morphology, functional groups, photoluminescence, and thermal stability of the developed systems are examined. The comparative studies performed among the pure HA, Sr 2+, and Ce 3+ ‐substituted HA nanoparticles illustrate higher antibacterial activity with lowered apatite‐forming ability and biocompatibility for the Ce 3+ ‐substituted HA. However, the Ce 3+ /Sr 2+ co‐substituted HA exhibits better biocompatibility, apatite‐forming ability, and good antimicrobial properties. Sr 2+ ion inclusion leads to better biological properties and compromise the cytotoxic nature of the Ce 3+ ‐HA. In addition, the Ce 3+ /Sr 2+ ‐HA nanoparticles prevent thermal decomposition up to 700°C, pointing also toward the possibility of this co‐substituted HA in bone implant applications. Abstract : Three defining dynamics of authentic participatory research