Bioactive food and exercise in chronic kidney disease: Targeting the mitochondria. (16th September 2018)

• Record Type: Journal Article
• Authors: Mafra, Denise; Gidlund, Eva‐Karin; Borges, Natália Alvarenga; Magliano, D'Angelo Carlo; Lindholm, Bengt; Stenvinkel, Peter; von Walden, Ferdinand
• Is Part Of: European journal of clinical investigation. Volume 48:Number 11(2018)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2018-09-16
• Subjects: chronic kidney disease -- exercise -- mitochondrial functions -- nutrition; Pathology -- Periodicals; Medical research -- Periodicals; 616.075
• DOI: 10.1111/eci.13020
• Languages: English
• ISSNs: 0014-2972

Abstract

Abstract: Chronic kidney disease (CKD), which affects 10%‐15% of the population, associates with a range of complications—such as cardiovascular disease, frailty, infections, muscle and bone disorders and premature ageing—that could be related to alterations of mitochondrial number, distribution, structure and function. As mitochondrial biogenesis, bioenergetics and the dynamic mitochondrial networks directly or indirectly regulate numerous intra‐ and extracellular functions, the mitochondria have emerged as an important target for interventions aiming at preventing or improving the treatment of complications in CKD. In this review, we discuss the possible role of bioactive food compounds and exercise in the modulation of the disturbed mitochondrial function in a uraemic milieu.