Gram‐scale production of carrier‐free fluorescent berberine microrods for selective liver cancer therapy. (26th October 2018)

• Record Type: Journal Article
• Authors: Zheng, Xiao; Zhang, Fan; Shao, Dan; Zhang, Zhanqiang; Cui, Lianzhi; Zhang, Jing; Dawulieti, Jianati; Meng, Zhaojie; Zhang, Ming; Chen, Li
• Is Part Of: BioFactors. Volume 44:Number 5(2018)
• Page Start: 496
• Page End: 502
• Publication Date: 2018-10-26
• Subjects: berberine -- gram‐scale -- micro‐rods -- carrier‐free; Vitamins -- Physiological effect -- Periodicals; Trace elements -- Physiological effect -- Periodicals; Growth factors -- Physiological effect -- Periodicals; Plant growth promoting substances -- Physiological effect -- Periodicals; Biochemistry -- Periodicals; Nutritional Physiological Phenomena -- Periodicals; Trace Elements -- metabolism -- Periodicals; Vitamins -- metabolism -- Periodicals; Molecular Biology -- Periodicals; 612.399
• DOI: 10.1002/biof.1450
• Languages: English
• ISSNs: 0951-6433

Abstract

Abstract: Berberine, a widely used isoquinoline alkaloid in traditional Chinese medicine, has been proved to be a potential candidate in liver cancer therapy. However, the low therapeutic dose in the tumor target which is due to the poor solubility and oral bioavailability has limited its clinical application. In this study, fluorescent self‐carried Berberine microrods (Ber‐MRs) were prepared in gram‐scale through a facile and cheap antisolvent precipitation method. Ber‐MRs exhibited good optical properties, pH‐responsive drug release behavior and selective and safe antitumor performance in vitro and in vivo without obvious toxicity. These findings have demonstrated that Ber‐MRs are promising for efficient and safe liver cancer therapy. © 2018 BioFactors, 44(5):496–502, 2018