Permanent wettability of a novel, nanoengineered, clinically available, hyaluronan‐coated dental implant. Issue 5 (5th September 2018)

• Record Type: Journal Article
• Authors: Morra, Marco; Cassinelli, Clara; Torre, Elisa; Iviglia, Giorgio
• Is Part Of: Clinical and experimental dental research. Volume 4:Issue 5(2018)
• Page Start: 196
• Page End: 205
• Publication Date: 2018-09-05
• Subjects: dental implants -- hydrophilicity -- wettability; Dentistry -- Periodicals; Dentistry; Oral Medicine; Mouth Diseases; Dentistry; Periodicals; Periodicals; Fulltext; Internet Resources; Periodicals; 617.6
• DOI: 10.1002/cre2.130
• Languages: English
• ISSNs: 2057-4347

Abstract

Abstract: The objectives of this study are to evaluate long‐term wettability of novel surface‐engineered, clinically available dental implants, featuring a surface nanolayer of covalently linked hyaluronan, and to confirm the relationships between wetting properties and surface nanostructure and microstructure. Wettability measurements were performed on clinically available hyaluronan‐coated Grade 4 titanium implants, packaged and sterile, that is, in the "on the shelf" condition, after 1 year from production. Wetting properties were measured by the Wilhelmy plate method. Analysis of the surface structure and chemistry was perfomed by X‐ray photoelectron spectroscopy (XPS), scanning electron microscopy (SEM) and energy‐dispersive X‐ray (EDX) analysis, atomic force microscopy (AFM), and ζ ‐potential measurement, either on implants or disks or plates subjected to the same surface‐engineering process. Results show that hydrophilicity and ensuing capillary rise of the hyaluronan‐coated implant surface is unaffected by aging and dry storage. Chemical analysis of the implant surface by XPS and evaluation of the ζ potential indicate that hyaluronan chemistry and not that of titanium dictates interfacial properties. Comparison between XPS versus EDX and SEM versus AFM data confirm that the thickness of the hyaluronan surface layer is within the nanometer range. Data show that nanoengineering of the implant surface by linking of the hydrophilic hyaluronan molecule endows tested titanium implants by permanent wettability, without need of wet storage as presently performed to keep long‐term hydrophilic implant surfaces. From an analytical point of view, the introduction in routine clinical practice of nanoengineered implant surfaces requires upgrading of analytical methods to the nanoscale.