Assessment of CEP55, PLK1 and FOXM1 expression in patients with bladder cancer in comparison with healthy individuals. (14th September 2018)

• Record Type: Journal Article
• Authors: Seyedabadi, Saman; Saidijam, Massoud; Najafi, Rezvan; Mousavi-Bahar, Seyed Habibollah; Jafari, Mohammad; MohammadGanji, Sajjad; Mahdavinezhad, Ali
• Is Part Of: Cancer investigation. Volume 36:Number 8(2018)
• Page Start: 407
• Page End: 414
• Publication Date: 2018-09-14
• Subjects: Urinary bladder neoplasm -- CEP55 -- FOXM1 -- Polo-like kinase 1 -- Biomarkers; Cancer -- Periodicals; Oncology -- Periodicals; Medical Oncology -- Periodicals; Neoplasms -- Periodicals; 616.994
• DOI: 10.1080/07357907.2018.1514504
• Languages: English
• ISSNs: 0735-7907

Abstract

Abstract: This case/control study is aimed at investigating the expression of CEP55, PLK1 and FOXM1 in bladder cancer tissues and comparing it with healthy tissue and their relationship with clinicopathological features of BC. Total RNA was extracted; then, gene expression was performed using real-time PCR relative to 18 s rRNA. 2 −ΔΔCT method was used to calculate the relative expression of genes. A significant over expression of FOXM1, PLK1 and CEP55 was observed in tumor samples compared to adjacent and normal bladder tissues (all p = 0.001). Therefore, they may be supposed as potential candidate's biomarkers for early diagnosis and targets for cancer therapy.