A single fluorescent probe for imaging ribonucleic acid and sulfur dioxide in living systems and its unique application in tumor and normal cells. Issue 41 (1st October 2018)

• Record Type: Journal Article
• Authors: Wang, Weishan; Liu, Yong; Niu, Jie; Lin, Weiying
• Is Part Of: Journal of materials chemistry. Volume 6:Issue 41(2018)
• Page Start: 6607
• Page End: 6614
• Publication Date: 2018-10-01
• Subjects: Materials -- Periodicals; Chemistry, Analytic -- Periodicals; Biomedical materials -- Research -- Periodicals; 543.0284
• DOI: 10.1039/c8tb02144a
• Languages: English
• ISSNs: 2050-750X

Abstract

Abstract : Herein, the development ofEPI-RS is described as the first paradigm of a probe that could image RNA and SO2 with distinct fluorescence signals in living systems. Abstract : To investigate the unique interrelation of ribonucleic acid (RNA) and sulfur dioxide (SO2 ) in living systems, it is necessary to construct novel molecular tools that could detect RNA and SO2 in living cancer cells and animals. Herein, we have constructed a unique fluorescent probe, EPI-RS, for imaging RNA and SO2 with distinct fluorescence signals in living systems. This type of probe shows a series of advantages, such as high photostability, large Stokes shift, high selectivity and sensitivity in a pure water system. In light of these advantages, the probeEPI-RS was employed to image RNA and SO2 by "turn on" and "turn off" fluorescence signals in living cells, tissues, zebrafish and mice. Interestingly, the probeEPI-RS exhibits different in vivo imaging properties in normal and tumor cells.