Janus nanocarriers for magnetically targeted and hyperthermia-enhanced curcumin therapy of liver cancer. Issue 53 (29th August 2018)

• Record Type: Journal Article
• Authors: Xing, Hao; Wang, Zheng; Shao, Dan; Chang, Zhimin; Ge, Mingfeng; Li, Li; Wu, Mingdi; Yan, Zhuangzhi; Dong, Wenfei
• Is Part Of: RSC advances. Volume 8:Issue 53(2018)
• Page Start: 30448
• Page End: 30454
• Publication Date: 2018-08-29
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/c8ra05694c
• Languages: English
• ISSNs: 2046-2069

Abstract

Abstract : Curcumin is regarded as a promising chemotherapeutic agent due to its anti-cancer activity and excellent biosafety. Abstract : Curcumin is regarded as a promising chemotherapeutic agent due to its anti-cancer activity and excellent biosafety. Nevertheless, the poor bioavailability and insufficient therapeutic efficacy have limited its further application in the clinic. Hence, we designed Janus magnetic mesoporous silica nanoparticles (Janus M-MSNs) for magnetically targeted and hyperthermia-enhanced curcumin treatment of liver cancer. In this study, curcumin was loaded into the silica components of Janus M-MSNs via surface-decorated pH-sensitive groups. Janus M-MSNs-Cur exhibited superior superparamagnetic properties, high curcumin loading ability and a tumor microenvironment-responsive curcumin release fashion. Additionally, an external magnetic field promoted the anti-tumor effectiveness of Janus M-MSNs-Cur through increasing the cellular internalization of Janus M-MSNs-Cur. More importantly, magnetic hyperthermia therapy supplemented the chemotherapeutic effect through a synergistic effect. Our outcomes demonstrated that Janus M-MSNs-Cur possessed a high therapeutic efficiency and excellent biosafety both in vitro and in vivo, indicating that Janus M-MSNs-Cur might be a promising therapeutic agent for liver cancer treatment.