Copper catalysis: ligand-controlled selective N-methylation or N-formylation of amines with CO2 and phenylsilane. Issue 21 (21st September 2018) - Li, Xue-Dong
Abstract : Selective N -formylation or N -methylation of amines was performed by subtly choosing the ligand in copper-promoted reductive functionalization of CO2 . Abstract : Cupric subcarbonate (Cu2 (OH)2 CO3 ) was found to be effective for the reductive functionalization of CO2 to produce formamides and methylamines with phenylsilane as reductant. Interestingly, N -formylation and N -methylation were switched on/off by subtly choosing the ligand: DPPB (1, 4-bis(diphenylphosphino)butane) promoted N -methylation whereas Ph2 CyP (diphenylcyclohexylphosphine) favored for N -formylation.