Electrochemiluminescence of gold nanoparticles and gold nanoparticle-labelled antibodies as co-reactants. Issue 63 (24th October 2018)

• Record Type: Journal Article
• Authors: Zhao, Changzhi; Niu, Lulu; Wang, Xiaoyu; Sun, Wei
• Is Part Of: RSC advances. Volume 8:Issue 63(2018)
• Page Start: 36219
• Page End: 36222
• Publication Date: 2018-10-24
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/c8ra07429a
• Languages: English
• ISSNs: 2046-2069

Abstract

Abstract : A new electrochemiluminescence system was discovered by combining electrochemiluminescence and AuNP-labelling technology based on electrochemiluminescence of AuNPs as a co-reactant. Abstract : Gold nanoparticles (AuNPs) and AuNP-labelled antibodies can participate in the electrochemiluminescence (ECL) reaction of tris(2, 2′-bipyridyl) ruthenium(ii ) (Ru(bpy)3 2+ ) as a co-reactant. The electrochemical and spectral characteristics of this new ECL system were confirmed by experiments, and its reaction mechanism was speculated to be different from that of typical ECL. The experimental results showed that the new ECL system exhibited higher ECL efficiency, and AuNP-labelled substances can be sensitively measured with the help of AuNPs. Based on the dual role of AuNPs as a co-reactant and marker, the AuNP–Ru(bpy)3 2+ ECL system will be a useful tool in biochemical analysis.