Multifunctional hyaluronic acid-derived carbon dots for self-targeted imaging-guided photodynamic therapy. Issue 41 (12th October 2018)

• Record Type: Journal Article
• Authors: Zhang, Lizhen; Lin, Zhaoxing; Yu, Yun-Xiang; Jiang, Bang-Ping; Shen, Xing-Can
• Is Part Of: Journal of materials chemistry. Volume 6:Issue 41(2018)
• Page Start: 6534
• Page End: 6543
• Publication Date: 2018-10-12
• Subjects: Materials -- Periodicals; Chemistry, Analytic -- Periodicals; Biomedical materials -- Research -- Periodicals; 543.0284
• DOI: 10.1039/c8tb01957f
• Languages: English
• ISSNs: 2050-750X

Abstract

Abstract : It is of vital importance to engineer the surface structures of carbon dots (CDs) to satisfy their practical biomedical applications, including imaging and treatment. Abstract : It is of vital importance to engineer the surface structures of carbon dots (CDs) to satisfy their practical biomedical applications, including imaging and treatment. In this work, one type of hyaluronic acid-derived CD (HA-CD) was synthesized via a facile one-step hydrothermal method using cancer cell-targeted HA as a precursor. The as-prepared HA-CDs were targeted actively toward CD44 receptor-overexpressing cancer cells because a partial HA structure remained on the HA-CD surface. Beyond this, HA-CDs can act as a novel photosensitizer, because they can generate O2 ˙ − under 650 nm laser irradiation, and they also exhibit excellent blue photoluminescence emission. The in vitro results revealed that HA-CDs imaged selectively CD44-overexpressing cancer cells and inhibited their growth under 650 nm laser irradiation. Thus, HA-CDs can serve as a promising self-targeted imaging-guided photodynamic therapy (PDT) agent for cancer. The present research provides a promising new method to simply construct multifunctional CD-based targeted phototheranostic systems.