Metal-free synthesis of fulleropyrrolidin-2-ols: a novel reaction of [60]fullerene with amines and 2, 2-disubstituted acetaldehydes. Issue 41 (4th October 2018)

• Record Type: Journal Article
• Authors: Huang, Gang; Zhang, Meng; Wang, Hui-Juan; Li, Fa-Bao; Yang, Fei; Liu, Li; Liu, Chao-Yang; Asiri, Abdullah M.; Alamry, Khalid A.
• Is Part Of: Organic & biomolecular chemistry. Volume 16:Issue 41(2018)
• Page Start: 7648
• Page End: 7656
• Publication Date: 2018-10-04
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/c8ob01903g
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : The reaction of [60]fullerene with amines and 2, 2-disubstituted acetaldehydes in the absence of metal salts afforded a series of novel fulleropyrrolidin-2-ols in moderate yields. Abstract : A series of scarce fulleropyrrolidin-2-ols were synthesized by the facile one-step reaction of [60] fullerene with inexpensive and readily accessible amines and 2, 2-disubstituted acetaldehydes without the addition of valuable metal salts in moderate yields, comparable to those for most monoadducts reported previously. This strategy exhibits a broad substrate scope and excellent functional group tolerance. A plausible reaction pathway for the formation of fulleropyrrolidin-2-ols is proposed to elucidate the above reaction process.