Abstract : A novel cross-linked supramolecular polymer network was prepared inspired by mussel yield catechol–Fe 3+ coordination and pillar[5]arene-based host–guest recognition. Abstract : Here a novel cross-linked supramolecular polymer network with thermal, pH, and H2 S responsiveness was prepared inspired by mussel yield catechol–Fe 3+ coordination and pillar[5]arene-based host–guest interactions.