Clinicopathological and Prognostic Value of CD24 Expression in Breast Cancer: A Meta-Analysis. Issue 2 (April 2017)

• Record Type: Journal Article
• Authors: Liu, Gao; Liu, Guo-Xing; Fang, Yu; Cao, Zhen-Yu; Du, Hui-Hui; Fu, Jie; Qian, Ke
• Is Part Of: International journal of biological markers. Volume 32:Issue 2(2017)
• Page Start: 182
• Page End: 189
• Publication Date: 2017-04
• Subjects: Breast cancer -- CD24 -- Meta-analysis -- Prognosis; Cell receptors -- Periodicals; Histochemistry -- Periodicals; Tumor markers -- Periodicals; Tumor antigens -- Periodicals; 616.99407582
• DOI: 10.5301/jbm.5000254
• Languages: English
• ISSNs: 0393-6155

Abstract

Background: A number of studies have been conducted to explore the relationship between CD24 expression and the prognosis of breast cancer; however, the results remain inconsistent. Therefore, we performed this meta-analysis to clarify the impact of CD24 expression on clinicopathological features and prognosis of breast cancer. Methods: A comprehensive literature search for relevant studies was performed, and statistical analysis was conducted using Stata software. Results: Twenty studies, including 5, 179 cases, were included in this meta-analysis. The pooled analysis indicated that CD24 expression was associated with lymph node invasion (odds ratio [OR] = 0.68, for negative vs. positive, 95% confidence interval [95% CI], 0.53-0.87, p = 0.002) and TNM stage (OR = 0.63, for I + II vs. III + IV, 95% CI, 0.49-0.81, p<0.001). The prognosis analysis also suggested CD24 overexpression indicated a poorer 5-year overall survival (OS) rate (relative risk ratio [RR] = 0.93, 95% CI, 0.86-0.99, p = 0.03) and 5-year disease-free survival (DFS) rate (RR = 0.90, 95% CI, 0.83-0.98, p = 0.02). However, CD24 expression had no correlation with tumor size, tumor grade, distance metastasis, estrogen receptor (ER) status, progesterone receptor (PR) status, or HER2 status. Conclusions: Our results suggest that higher CD24 expression is significantly associated with lower OS rate, lower DFS rate and some clinicopathological factors such as lymph node invasion and TNM stage. This meta-analysis suggested that CD24 is an efficient prognostic factor in breast cancer.