XRCC1 Arg399Gln Gene Polymorphism and Hepatocellular Carcinoma Risk in the Italian Population. Issue 2 (April 2017)

• Record Type: Journal Article
• Authors: Santonocito, Concetta; Scapaticci, Margherita; Nedovic, Bojan; Annicchiarico, Eleonora B.; Guarino, Donatella; Leoncini, Emanuele; Boccia, Stefania; Gasbarrini, Antonio; Capoluongo, Ettore
• Is Part Of: International journal of biological markers. Volume 32:Issue 2(2017)
• Page Start: 190
• Page End: 194
• Publication Date: 2017-04
• Subjects: Base excision repair -- Hepatocellular carcinoma risk -- XRCC1; Cell receptors -- Periodicals; Histochemistry -- Periodicals; Tumor markers -- Periodicals; Tumor antigens -- Periodicals; 616.99407582
• DOI: 10.5301/jbm.5000241
• Languages: English
• ISSNs: 0393-6155

Abstract

Background: The human X-ray repair cross-complementing protein 1 ( XRCC1 ) gene encodes for one of the major repair factors involved in base excision repair (BER), which is reported to be associated with the risk of several cancers. A few studies have explored the association between risk of hepatocellular carcinoma (HCC) and single-nucleotide polymorphisms (SNPs) in different DNA repair genes, with contradictory results. The purpose of this study was to evaluate the association between XRCC1 Arg399Gln polymorphism and susceptibility to HCC. Methods: A total of 89 HCC patients and 99 randomly selected healthy controls were enrolled. Genotyping of XRCC1 rs25487 was performed by high-resolution melting analysis and Sanger sequencing. Results: On univariate analysis, a statistically significant association was found between risk of HCC and XRCC1 399Arg/Gln genotype (odd ratio [OR] = 1.88; 95% CI, 1.04-3.43), which was confirmed after adjusting by sex (OR = 1.94; 95% CI, 1.04-3.63). Although not significant, Kaplan-Meier analysis showed a decreased median survival in Arg/Gln genotype carriers in comparison with Arg/Arg carriers. Conclusions: To our knowledge, this is the first study reporting an association between BER SNP and HCC risk in a population of central-southern Italy.