Infection-mediated autoimmune movement disorders. (January 2018)

• Record Type: Journal Article
• Authors: Cucca, Alberto; Migdadi, Hamzeh A.; Di Rocco, Alessandro
• Is Part Of: Parkinsonism & related disorders. Volume 46(2018)Supplement 1
• Page Start: S83
• Page End: S86
• Publication Date: 2018-01
• Subjects: Movement disorders -- Autoimmune -- Infection; Parkinson's disease -- Periodicals; Movement disorders -- Periodicals; Movement Disorders -- Periodicals; Nerve Degeneration -- Periodicals; Nervous System Diseases -- Periodicals; Parkinson Disease -- Periodicals; Tremor -- Periodicals; Parkinson, Maladie de -- Périodiques; Parkinson's disease; 616.833
• DOI: 10.1016/j.parkreldis.2017.07.019
• Languages: English
• ISSNs: 1353-8020

Abstract

Abstract: Infectious diseases remain the most common cause of neurological disability in the world. A number of movement disorders can develop in adults and children in response to infections. These can occur in isolation or as part of a broader neurological illness, with movement abnormalities consequent to an encephalopathy or a broader brain dysfunction. While most infection-related movement disorders are direct consequences of an active infectious process affecting cerebral structures implied in the motor network, at times a delayed immune-mediated process in response to a previous infectious is responsible for the neurological dysfunction. This immunological response can occur as a consequence of a number of pathogens, and develop at variable times after the initial infection. The most common infection-mediated autoimmune movement disorders are chorea, which is especially common in children, and other hyperkinetic disorders, but Parkinsonism and other hypokinetic movement disorders may also occur.