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Gas-liquid flow hydrogenation of nitroarenes: Efficient access to a pharmaceutically relevant pyrrolobenzo[1, 4]diazepine scaffold. Issue 47 (22nd November 2018)
Record Type:
Journal Article
Title:
Gas-liquid flow hydrogenation of nitroarenes: Efficient access to a pharmaceutically relevant pyrrolobenzo[1, 4]diazepine scaffold. Issue 47 (22nd November 2018)
Main Title:
Gas-liquid flow hydrogenation of nitroarenes: Efficient access to a pharmaceutically relevant pyrrolobenzo[1, 4]diazepine scaffold
Abstract: Using a Tube-in-Tube device based on the amorphous Teflon AF-2400 fluoropolymer, a series of nitroarenes was hydrogenated to afford the corresponding aniline compounds. The system was then applied to the construction of a pyrrolobenzo[1, 4]diazapene scaffold through a tandem hydrogenation-condensation-hydrogenation sequence. Graphical abstract: