The Relation between CA 19-9 level and Early-Phase Insulin Secretion in Normoglycemic and Prediabetic Subjects. Issue 2 (April 2015)

• Record Type: Journal Article
• Authors: Shimodaira, Masanori; Niwa, Tomohiro; Nakajima, Koji; Kobayashi, Mutsuhiro; Hanyu, Norinao; Nakayama, Tomohiro
• Is Part Of: International journal of biological markers. Volume 30:Issue 2(2015)
• Page Start: 169
• Page End: 173
• Publication Date: 2015-04
• Subjects: CA 19-9 -- Diabetes -- Disposition index -- Insulin secretion -- Prediabetes; Cell receptors -- Periodicals; Histochemistry -- Periodicals; Tumor markers -- Periodicals; Tumor antigens -- Periodicals; 616.99407582
• DOI: 10.5301/jbm.5000130
• Languages: English
• ISSNs: 0393-6155

Abstract

Background: Carbohydrate antigen (CA) 19-9 is used as a clinical tumor marker of pancreatic cancer; recent studies report that CA 19-9 is also associated with changes in blood glucose levels. The aim of the present study was to investigate the relationship between serum CA 19-9 levels and early-phase insulin secretion in nondiabetic individuals. Methods: We enrolled 269 normoglycemic participants and 172 prediabetic participants who had undergone the 75-g oral glucose tolerance test during their annual health examination. Insulin secretion was estimated using the disposition index (DI) [(Δinsulin(0-30 min) /Δglucose(0-30 min) × (1/HOMA-IR)], which is an adjusted measure of relationship between β-cell sensitivity and insulin sensitivity. Results: Serum CA 19-9 level was significantly higher in the prediabetic participants than in the normoglycemic participants. Simple linear regression analysis showed a negative correlation between CA 19-9 levels and DI for all participants and prediabetic participants (r = -0.126, p = 0.009, and r = -0.189, p = 0.002, respectively). However, in the normoglycemic participants, CA 19-9 levels did not correlate with DI. For all participants, and prediabetic subjects, multivariate linear regression analysis revealed that serum CA 19-9 levels were one of the independent predictors of DI (adjusted β = -0.098, p = 0.025, and adjusted β = -0.177, p = 0.004, respectively). Conclusions: Serum CA 19-9 levels significantly correlate with early-phase insulin secretion in the prediabetic individuals. Our results indicate that CA 19-9 may be involved in the endocrine function of pancreas.