FBXW7 Mutation Analysis and its Correlation with Clinicopathological Features and Prognosis in Colorectal Cancer Patients. Issue 1 (January 2015)

• Record Type: Journal Article
• Authors: Chang, Chia-Chu; Lin, Hung-Hsin; Lin, Jen-Kou; Lin, Chun-Chi; Lan, Yuan-Tzu; Wang, Huann-Sheng; Yang, Shung-Haur; Chen, Wei-Shone; Lin, Tzu-Chen; Jiang, Jeng-Kai; Chang, Shih-Ching
• Is Part Of: International journal of biological markers. Volume 30:Issue 1(2015)
• Page Start: 88
• Page End: 95
• Publication Date: 2015-01
• Subjects: Colorectal cancer -- FBXW7 -- Overall survival -- Tumor suppressor gene; Cell receptors -- Periodicals; Histochemistry -- Periodicals; Tumor markers -- Periodicals; Tumor antigens -- Periodicals; 616.99407582
• DOI: 10.5301/jbm.5000125
• Languages: English
• ISSNs: 0393-6155

Abstract

Purpose: This study aimed to determine the prognostic value of mutations in the tumor suppressor gene FBXW7 for clinical outcomes in colorectal cancer (CRC). Methods: Between January 2000 and December 2009, FBXW7 mutations in tumor tissues from 1, 519 CRC patients at Taipei Veterans General Hospital were assessed using a MassArray system. We compared the clinicopathological variables and prognosis between the wild-type and mutant tumor tissue groups. Results: FBXW7 mutations were present in 114/1, 519 CRC patients (7.5%). In stage I/II CRC patients, mutant FBXW7 was more common than wild-type FBXW7 (62.3% vs. 50.8%). CRC patients with FBXW7 mutations did not differ significantly in their 5-year overall survival (OS). Stage I/II CRC patients with FBXW7 mutations had lower OS, but this difference was not significant (71.6% vs. 78.2%). Among FBXW7 tumors, S582L was the most frequent mutation type (19.3%), followed by R465H (16.6%), R505C (14.9%) and R479Q (14.9%). Subgroup analysis of FBXW7 mutants showed that R465H/R465C/R479Q had better 5-year OS than other mutant types (76.9% vs. 56.0%; p=0.012). Conclusions: There was no strong association between patient prognosis and FBXW7 mutations in our large-scale study.