Dynamic expression of p75NTR and Lingo-1 during development of mouse retinofugal pathway. (1st November 2018)

• Record Type: Journal Article
• Authors: Wang, Liqing; Yu, Chao; Sun, Xiaobo; Chan, Sun-On
• Is Part Of: Neuroscience letters. Volume 686(2018)
• Page Start: 106
• Page End: 111
• Publication Date: 2018-11-01
• Subjects: RGCs retinal ganglion cells -- p75NTR the low-affinity neurotrophic receptor -- NgR Nogo-66 receptor; Axon guidance -- Visual system -- Optic chiasm -- p75 NTR -- Lingo-1 -- NgR; Neurology -- Periodicals; Neurology -- Periodicals; Research -- Periodicals; Neurologie -- Périodiques; Neuroanatomie -- Périodiques; Neuropharmacologie -- Périodiques; Neurophysiologie -- Périodiques; Neurology; Periodicals; Electronic journals; 617.48
• DOI: 10.1016/j.neulet.2018.09.012
• Languages: English
• ISSNs: 0304-3940

Abstract

Highlights: p75 NTR was detected in retinal ganglion cells and their axons during the time of axon growth in the optic chiasm. Lingo-1 was observed in RGC but not on axons at the optic disk, and was localized on axons along the optic pathway. Lingo-1 also showed a glial localization at the optic disc and a neuronal localization in chiasmatic neurons. Abstract: Our previous studies showed interaction of Nogo at the midline with its receptor (NgR) on optic axons plays a role in axon divergence at the mouse optic chiasm. Since NgR lacks a cytoplasmic domain, it needs transmembrane receptor partners for signal transduction. In this study, we examined whether the co-receptors of NgR, low-affinity neurotrophic receptor (p75 NTR ) and Lingo-1, are localized on axons in the mouse optic pathway. In the retina, p75 NTR and Lingo-1 were observed on neuroepithelial cells at E13 and later on the retinal ganglion cells at E14 and E15. At the optic disc, p75 NTR was observed on the retinal axons, whereas Lingo-1 was found on glial processes surrounding the axon fascicles. Both p75 NTR and Lingo-1 were found on axons in the optic stalk, optic chiasm and optic tract. Furthermore, a transient expression of Lingo-1 was observed on the SSEA-1 positive chiasmatic neurons at E13, but not at later developmental stages. The presence of p75 NTR and Lingo-1 on optic axons provides further supports to the contribution of Nogo/NgR signaling in axon divergence at the mouse optic chiasm.