Cancellous Bone Response to Strontium-Doped Hydroxyapatite in Osteoporotic Rats. Issue 1 (January 2015)

• Record Type: Journal Article
• Authors: Li, Yunfeng; Luo, En; Zhu, Songsong; Li, Jihua; Zhang, Li; Hu, Jing
• Is Part Of: Journal of applied biomaterials & functional materials. Volume 13:Issue 1(2015)
• Page Start: 28
• Page End: 34
• Publication Date: 2015-01
• Subjects: Bone formation -- Hydroxyapatite -- Implant -- Osteoporosis -- Strontium; Biomedical materials -- Periodicals; Bioengineering -- Periodicals; Biomechanics -- Periodicals; 610.28
• DOI: 10.5301/jabfm.5000168
• Languages: English
• ISSNs: 2280-8000

Abstract

Purpose: The objective of this study was to investigate cancellous bone response to strontium-doped hydroxyapatite (SrHA) in ovariectomized (OVX) rats. Methods: Hydroxyapatite (HA) and 10%SrHA (HA with 10 mol% calcium substituted by strontium) implants were prepared and characterized by scanning electronic microscopy (SEM), energy dispersive microanalysis (EDX) and X-ray diffraction (XRD). Twelve weeks after bilateral ovariectomy, 20 rats randomly received HA or 10%SrHA implants in the right distal femur, with 10 animals in each group. Eight weeks after implantation, specimens were harvested and analyzed by micro-computed tomography (micro-CT) and histology. Results: Compared with HA, 10%SrHA raised the percentage bone volume by 42.6%, bone-to-implant contact by 47.1%, mean trabecular number by 27.3%, mean trabecular thickness by 31.5% and mean connectivity density by 37.4%, while it decreased mean trabecular separation by 20.1% in micro-CT evaluation. 10%SrHA also increased the bone area density by 47.6% in histological analysis. Conclusions: With the HA implants as controls, the 10%SrHA implants were shown to increase bone density and bone-to-implant contact, and improve trabecular architecture in the vicinity of implant surfaces.