Copper-promoted Chan-Lam coupling between enaminones and aryl boronic acids. Issue 47 (21st November 2018)

• Record Type: Journal Article
• Authors: Duan, Xiyan; Liu, Ning; Liu, Kun; Song, Yakun; Wang, Jia; Mao, Xianhua; Xu, Weidong; Yang, Shijie; Li, Huixian; Ma, Junying
• Is Part Of: Tetrahedron letters. Volume 59:Issue 47(2018)
• Page Start: 4187
• Page End: 4190
• Publication Date: 2018-11-21
• Subjects: HMISYHGFKCQJIH-SILNSSARSA-N -- CPXIEIPOTWVOGV-PGMHBOJBSA-N -- SQVBMSBLPYNBJM-PGMHBOJBSA-N -- QMVYXRRDVMZUQQ-HKWRFOASSA-N -- IZHQZYJLGNLOEK-HKWRFOASSA-N -- UENNOEFSMMSBKA-PGMHBOJBSA-N -- TXCNNYDRZCJFIT-HKWRFOASSA-N -- RBCJMCUFFRPUKX-HKWRFOASSA-N -- GCVLSOFEJQUGQM-HKWRFOASSA-N -- NYLCXQLAWPNPLQ-SILNSSARSA-N -- VFOCINBDEBFJRH-QNGOZBTKSA-N -- YJDLPRQHWSLKNQ-HKWRFOASSA-N -- HGNIRTDPHVXUDV-MOHJPFBDSA-N -- PIBAZJRLQNJFLJ-QINSGFPZSA-N -- RPPGKFCUTBBWHM-VKAVYKQESA-N -- NAQTVFZEDULYOT-VKAVYKQESA-N -- DHNMUFHATVXLCF-SDXDJHTJSA-N -- UACJGNASLHMIKG-PGMHBOJBSA-N -- PMGFOBXTODBOKI-PGMHBOJBSA-N -- DIVBHUSRQVBOSU-HKWRFOASSA-N -- QKIVXJWZCCWBGJ-HKWRFOASSA-N -- MRAIUEFJWPOCLU-HKWRFOASSA-N -- HZRDMCYPLISZGT-H KWRFOASSA-N -- AVNVZDPHTUJSQS-BWAHOGKJSA-N -- HIHMZTLSFVFKCU-UHFFFAOYSA-N -- LVMHTARDQMFJFA-UHFFFAOYSA-N; Copper-promoted -- Chan-Lam coupling -- Enamines -- Aryl boronic acids -- C–N bond formation; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tetlet.2018.10.030
• Languages: English
• ISSNs: 0040-4039

Abstract

Graphical abstract: Highlights: Chan-Lam coupling between enaminones and aryl boronic acids. Our approach provides accesses to N -aryl enaminones bearing multiple aromatic rings. The reaction can be conducted on gram scale. Abstract: A novel copper-promoted N- arylation of enaminones with aromatic boronic acids has been developed, which provides an efficient way to synthesize N -aryl enaminones with a broad substrate scope and excellent functional group compatibility. The N -aryl enaminones could be converted into a series of highly valuable building blocks and bioactive compounds. Notably, in comparison with traditional methods, this alternative approach provides accesses to N -aryl enaminones bearing multiple aromatic rings.