Copper(II)-catalyzed-α-C(sp3)-H activation of cyclic amines: A simple and efficient strategy for the synthesis of fused pyrazole derivatives. Issue 47 (21st November 2018)

• Record Type: Journal Article
• Authors: Regalla, Venkata Reddy; Addada, RamaKrishnam Raju; Chatterjee, Anindita
• Is Part Of: Tetrahedron letters. Volume 59:Issue 47(2018)
• Page Start: 4161
• Page End: 4164
• Publication Date: 2018-11-21
• Subjects: Fused pyrazoles -- Cross dehydrogenative coupling -- Hydroamination -- CH functionalization -- Aerial oxidation; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tetlet.2018.10.017
• Languages: English
• ISSNs: 0040-4039

Abstract

Graphical abstract: Highlights: Development of simple and efficient strategy for synthesis of fused pyrazole derivatives. To design coupling reactions with suitable substrates towards targeted products. Abstract: In this paper, we have described a simple and efficient strategy for the synthesis of fused pyrazole derivatives. The key steps of our strategy involves hydroamination, copper-catalyzed cross dehydrogenative coupling (CDC) followed by aromatization (aerial oxidation) in one-pot. Our strategy offers a valuable alternative to known methods for synthesis of fused pyrazole derivatives. Overall, we have synthesized 13 diverse fused pyrazole derivatives in moderate to excellent yields.