Dietary intake of pyrolyzed deketene curcumin inhibits gastric carcinogenesis. (November 2018)

• Record Type: Journal Article
• Authors: Yoshida, Taichi; Maruyama, Takashi; Miura, Masatomo; Inoue, Masahiro; Fukuda, Koji; Shimazu, Kazuhiro; Taguchi, Daiki; Kanda, Hiroaki; Oshima, Masanobu; Iwabuchi, Yoshiharu; Shibata, Hiroyuki
• Is Part Of: Journal of functional foods. Volume 50(2018)
• Page Start: 192
• Page End: 200
• Publication Date: 2018-11
• Subjects: Curcumin -- Chemoprevention -- Diarylpentanoid analog -- Gastric cancer -- Pyrolysis -- STAT3 inhibition; C5 diarylpentanoid -- STAT3 signal transducers and activators of transcription 3; Functional foods -- Analysis -- Periodicals; Food -- Biotechnology -- Periodicals; Nutrition -- Periodicals; 613.2
• DOI: 10.1016/j.jff.2018.09.033
• Languages: English
• ISSNs: 1756-4646

Abstract

Graphical abstract: Highlights: GO-Y022 exerts higher inhibitory effects on the growth of gastric cancer cells than curcumin. Orally administrated GO-Y022 reduced the gastric tumor volume to a third in mice fed with a basal diet. GO-Y022 can inhibit STAT3 phosphorylation, one of the major molecules contributing gastric carcinogenesis. Five milligram daily intake of GO-Y022 is safe in mice. GO-Y022 is detected in commercial curry pastes and could be a functional food. Abstract: Gastric cancer is the second leading cause of cancer-related mortality worldwide. Curcumin, a phytochemical, possesses molecular inhibitory potentials for regulating malignancies. However, the lower potential of curcumin warrants improvement. Thus, we synthesized diarylpentanoid analogs with higher potency; however, these differed structurally from curcumin—a heptanoid. Recently, one diarylpentanoid was formed following pyrolysis of curcumin, which is identical to our GO-Y022. The growth inhibition of gastric cancer cells by GO-Y022 was five-fold higher than by curcumin; GO-Y022 displayed superior apoptosis induction ability. Besides, it suppressed the gastric tumor growth to a third in a mouse model. GO-Y022 was moved to the epithelial and gastric tumors but not detected in the bloodstream. Moreover, oral GO-Y022 was effective topically, exhibited no adverse events in mice, and was detected in the commercially available curry paste. Briefly, GO-Y022 can inhibit gastric carcinogenesis; it is dietary and can be safely used as an oral functional food.