Multi‐shelled Dendritic Mesoporous Organosilica Hollow Spheres: Roles of Composition and Architecture in Cancer Immunotherapy. Issue 29 (3rd May 2017)

• Record Type: Journal Article
• Authors: Yang, Yannan; Lu, Yao; Abbaraju, Prasanna Lakshmi; Zhang, Jun; Zhang, Min; Xiang, Guangya; Yu, Chengzhong
• Is Part Of: Angewandte Chemie international edition. Volume 56:Issue 29(2017)
• Page Start: 8446
• Page End: 8450
• Publication Date: 2017-05-03
• Subjects: adjuvants -- antitumor activity -- immunotherapy -- multi-shelled materials -- organosilica; Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201701550
• Languages: English
• ISSNs: 1433-7851

Abstract

Abstract: Developing potent adjuvants for the stimulation of robust immune response is central for effective cancer immunotherapy. Double‐shelled dendritic mesoporous organosilica hollow spheres are an excellent adjuvant and provide superior immunity in cancer immunotherapy, and better than their counterparts either with a pure silica composition or a single‐walled architecture. This study provides new insights in the rational design of effective nanostructured adjuvants for vaccine developments. Abstract : Multi‐shelled dendritic mesoporous organosilica hollow spheres were synthesized and developed as potent antitumor immuno‐adjuvants. Compared to a single shelled structure or pure silica composition, double‐shell organosilica nanoparticles showed significantly improved cancer immunotherapy efficacy in vivo. Crucial are the roles of the unique architecture and the hybrid composition.