Pharmacokinetics of Mycophenolic Acid after Intravenous Administration of Mycophenolate Mofetil to Healthy Cats. (11th September 2017)

• Record Type: Journal Article
• Authors: Slovak, J.E.; Rivera, S.M.; Hwang, J.K.; Court, M.H.; Villarino, N.F.
• Is Part Of: Journal of veterinary internal medicine. Volume 31:Number 6(2017)
• Page Start: 1827
• Page End: 1832
• Publication Date: 2017-09-11
• Subjects: Cats -- Immunosuppressant -- Mycophenolate mofetil -- Pharmacokinetics; Veterinary medicine -- Periodicals; 636.0896
• DOI: 10.1111/jvim.14827
• Languages: English
• ISSNs: 0891-6640

Abstract

Abstract : Background: Mycophenolate mofetil (MMF), the prodrug of mycophenolic acid (MPA), is becoming increasingly popular as an alternative immunosuppressant in feline medicine. Pharmacokinetic information is not available for cats. Objective: The purpose of this study was to determine whether MMF is biotransformed into the active metabolite MPA and to evaluate the disposition of MPA after a 2‐hour constant rate intravenous (IV) infusion of MMF in healthy cats. Animals: Healthy cats (n = 6). Methods: This was a prospective pilot study. All cats were administered MMF at 20 mg/kg every 12 hours over a 2‐hour constant rate infusion for 1 day. The concentrations of MPA and its derivatives in blood were determined using a validated UHPLC–UV method. Results: All cats biotransformed MMF into MPA. The mean AUC0‐14 h ranged from 6 to 50 h*mg/L after IV dosing of MMF. Transient large bowel diarrhea was recorded in 2 of 6 cats after medication administration. Conclusion and Clinical Importance: The disposition of MPA in plasma was highly variable, which could result in high interindividual variability in the safety and efficacy of treatment with MMF in cats.