Granisetron plus dexamethasone for prevention of postoperative nausea and vomiting in patients undergoing laparoscopic surgery: A meta-analysis. (June 2017)

• Record Type: Journal Article
• Authors: Zhu, Min; Zhou, Chengmao; Huang, Bing; Ruan, Lin; Liang, Rui
• Is Part Of: Journal of international medical research. Volume 45:Number 3(2017)
• Page Start: 904
• Page End: 911
• Publication Date: 2017-06
• Subjects: Granisetron -- dexamethasone -- laparoscopic surgery -- postoperative nausea and vomiting -- meta-analysis; Medicine -- Periodicals; Pharmacology -- Periodicals; 610.5
• DOI: 10.1177/0300060517703276
• Languages: English
• ISSNs: 0300-0605

Abstract

Objective: This study was designed to compare the effectiveness of granisetron plus dexamethasone for preventing postoperative nausea and vomiting (PONV) in patients undergoing laparoscopic surgery. Methods: We searched the literature in the Cochrane Library, PubMed, EMBASE, and CNKI. Results: In total, 11 randomized controlled trials were enrolled in this analysis. The meta-analysis showed that granisetron in combination with dexamethasone was significantly more effective than granisetron alone in preventing PONV in patients undergoing laparoscopy surgery. No significant differences in adverse reactions (dizziness and headache) were found in association with dexamethasone. Conclusion: Granisetron in combination with dexamethasone was significantly more effective than granisetron alone in preventing PONV in patients undergoing laparoscopic surgery, with no difference in adverse reactions between the two groups. Granisetron alone or granisetron plus dexamethasone can be used to prevent PONV in patients undergoing laparoscopic surgery.