Common genetic risk variants are associated with positive symptoms and decision-making ability in patients with schizophrenia. Issue 1 (30th September 2015)

• Record Type: Journal Article
• Authors: Martin, Andrew K.; Robinson, G.; Reutens, D.; Mowry, B.
• Is Part Of: Psychiatry research. Volume 229:Issue 1/2(2015)
• Page Start: 606
• Page End: 608
• Publication Date: 2015-09-30
• Subjects: Cognition -- Polygene risk scores -- Positive symptoms; Psychiatry -- Periodicals; Psychiatry -- periodicals; Psychiatrie -- Périodiques; 616.89
• DOI: 10.1016/j.psychres.2015.04.045
• Languages: English
• ISSNs: 0165-1781

Abstract

Abstract: Schizophrenia is a clinically heterogeneous disorder associated with broad deficits across cognitive domains. As large genomewide association studies uncover the genetic architecture of schizophrenia, the relationship between common genetic variants and clinical and cognitive characteristics will form part of an integrative approach to understanding genetic effects on the clinical phenotype. In the current study, association between common genetic risk variants and clinical and cognitive variables was investigated. Common risk variants were associated with positive symptoms and decision-making ability from the Cambridge Gambling Task with trends in other domains. Highlights: Polygenic risk scores are associated with quality of decision-making from the Cambridge Gambling task. Polygenic risk scores are associated with positive symptoms. Suggestive association between language ability and polygenic risk scores.