Computation of entropy and energetics profiles of a single-stranded viral DNA. (3rd August 2011)

• Record Type: Journal Article
• Authors: Neelakanta, Perambur S.; Chatterjee, Sharmistha; Thengum-Pallil, George A.
• Is Part Of: International journal of bioinformatics research and applications. Volume 7:Number 3(2011)
• Page Start: 239
• Page End: 261
• Publication Date: 2011-08-03
• Subjects: ssDNA -- single-stranded DNA -- viral genome -- entropy -- energetics -- hairpin-bending -- codon-non-codon delineation -- CpG island -- vaccine design; Bioinformatics -- Periodicals; 570.285
• Languages: English
• ISSNs: 1744-5485

Abstract

The bioinformatic aspects of computing entropy and energetic profiles associated with a viral single-stranded DNA (ssDNA) are addressed. The analyses envisaged thereof determine the structural (stem and loop) features, identify the CpG motifs and delineate the boundaries of coding DNA segments along a test viral (B19) ssDNA. The analytical modelling and computational efforts conform to Shannon entropy and thermodynamic kinetics of the test genome. Results are presented toward validation against available data. Pertinent details are reviewed in the context of their possible uses in rational vaccine designs.