Bagged gene shaving for the robust clustering of high-throughput data. (12th October 2010)

• Record Type: Journal Article
• Authors: Broom, Bradley M.; Sulman, Erik P.; Do, Kim-Anh; Edgerton, Mary E.; , Kenneth D. Aldape
• Is Part Of: International journal of bioinformatics research and applications. Volume 6:Number 4(2010)
• Page Start: 326
• Page End: 343
• Publication Date: 2010-10-12
• Subjects: bootstrap aggregation -- clustering -- gene shaving clusters -- glioblastoma -- bioinformatics -- microarray data -- brain tumour samples -- brain tumours; Bioinformatics -- Periodicals; 570.285
• Languages: English
• ISSNs: 1744-5485

Abstract

The analysis of high-throughput data sets, such as microarray data, often requires that individual variables (genes, for example) be grouped into clusters of variables with highly correlated values across all samples. Gene shaving is an established method for generating such clusters, but is overly sensitive to the input data: changing just one sample can determine whether or not an entire cluster is found. This paper describes a clustering method based on the bootstrap aggregation of gene shaving clusters, which overcomes this and other problems, and applies the new method to a large gene expression microarray dataset from brain tumour samples.