Rapid Infliximab Infusion in Children: A Multicenter Retrospective Cohort Study. Issue 5 (November 2017)

• Record Type: Journal Article
• Authors: Lev-Tzion, Raffi; Assa, Amit; Yerushalmi, Baruch; Lahad, Avishay; Friedman, Mira; Ledder, Oren; Turner, Dan
• Is Part Of: Journal of pediatric gastroenterology and nutrition. Volume 65:Issue 5(2017)
• Publication Date: 2017-11
• Subjects: Crohn disease -- inflammatory bowel disease -- infusion reaction -- pediatric -- ulcerative colitis; Children -- Nutrition -- Periodicals; Pediatric gastroenterology -- Periodicals; Infants -- Nutrition -- Periodicals; Nutrition disorders in children -- Periodicals; Child Nutrition -- Periodicals; Digestive System -- growth & development -- Periodicals; Gastrointestinal Diseases -- Periodicals; Infant Nutrition -- Periodicals; Nutrition Disorders -- Periodicals; Child; 618.923
• DOI: 10.1097/MPG.0000000000001615
• Languages: English
• ISSNs: 0277-2116

Abstract

Abstract : ABSTRACT: Pediatric data on rapid infliximab infusion are scarce. We report our experience with a 1-hour rapid infusion protocol, prescribed in 3 pediatric inflammatory bowel disease units during 18 to 26 months. Children treated with infliximab for inflammatory bowel disease using a standard 2- to 3-hour infusion protocol were switched to a 1-hour protocol if they had received at least 4 standard duration infusions with no infusion reactions, there was no recent dose increase and no more than 10 weeks had elapsed since the previous infusion. A total of 102 children received infliximab infusions during the study period (85 Crohn disease; mean age 14.6 ± 2.6 years) of whom 63 were switched to the rapid infusions. Seven patients on the rapid protocol (11%) and 6 patients on the standard protocol (15%) had infusion reactions ( P = 0.55). Consistent with adult data, our study indicates that a 1-hour infliximab protocol in selected patients offers a safe alternative to the traditional 2- to 3-hour infusions.