Exploration of homodimer receptor: homodimer protein interactions. (29th July 2009)

• Record Type: Journal Article
• Authors: Vera, Julio; Kwon, Taesoo; Schmitz, Ulf; Kolch, Walter; , Olaf Wolkenhauer
• Is Part Of: International journal of bioinformatics research and applications. Volume 5:Number 4(2009)
• Page Start: 447
• Page End: 457
• Publication Date: 2009-07-29
• Subjects: cell signalling -- homodimerisation -- homodimer receptors -- homodimer proteins -- transducers -- protein?protein interactions -- systems biology -- bioinformatics -- gene ontology -- human cells; Bioinformatics -- Periodicals; 570.285
• Languages: English
• ISSNs: 1744-5485

Abstract

Homodimerisation is producing a protein?protein complex composed of two identical molecules. Dimerisation is a phenomenon often occurring in the regulation of biochemical systems like signal transduction pathways. We investigated whether the existence of a homodimer-activated receptor and the activation of homodimer transducers correspond to a more general pattern in cell signalling. We developed a workflow to merge data from the Gene Ontology and the BIND database to produce a list of interactions between homodimer receptors and homodimer proteins. Finally, we found a prevalence of homodimer?homodimer interactions in signalling systems in human cells.