Soft Tissue Response on 18F-Fluorocholine PET/CT in Metastatic Castrate-Resistant Prostate Cancer Treated With 223Ra-Dichloride: A Possible Abscopal Effect?. (November 2017)

• Record Type: Journal Article
• Authors: Kwee, Sandi A.; Lim, John; Coel, Marc N.
• Is Part Of: Clinical nuclear medicine. Volume 42:Number 11(2017)
• Publication Date: 2017-11
• Subjects: 223Ra -- abscopal -- castrate-resistant prostate cancer -- fluorocholine -- PET; Nuclear medicine -- Periodicals; Radioisotope scanning -- Periodicals; Nuclear Medicine -- Periodicals; 616.07575
• DOI: 10.1097/RLU.0000000000001807
• Languages: English
• ISSNs: 0363-9762

Abstract

Abstract : Abstract: Two patients with castrate-resistant prostate cancer and symptomatic skeletal metastases underwent 18 F-fluorocholine PET/CT prior to treatment with 223 Ra-dichloride to reveal additional active lesions in the prostate gland and lymph nodes. Subsequent scans performed at the midpoint and end of 223 Ra-dichloride therapy showed resolution of this soft tissue activity alongside declining bone lesion activity. Concomitant increases in plasma interleukin 6 were detected, suggesting that immune system activation may have mediated the soft tissue response. Abscopal effects usually encountered with external beam radiotherapy may also be occurring with 223 Ra-dichloride therapy.