MEG May Reveal Hidden Population of Spikes in Epilepsy With Porencephalic Cyst/Encephalomalacia. Issue 6 (November 2017)

• Record Type: Journal Article
• Authors: Kakisaka, Yosuke; Wang, Zhong I.; Shibata, Sumiya; Takahashi, Yoko; Mosher, John C.; Alexopoulos, Andreas V.; Burgess, Richard C.
• Is Part Of: Journal of clinical neurophysiology. Volume 34:Issue 6(2017)
• Publication Date: 2017-11
• Subjects: Magnetoencephalography -- EEG -- Porencephalic cyst/encephalomalacia -- Epilepsy; Electroencephalography -- Periodicals; Neurophysiology -- Periodicals; Electroencephalography -- Periodicals; Electroencephalography; Periodicals; 612.805
• DOI: 10.1097/WNP.0000000000000362
• Languages: English
• ISSNs: 0736-0258

Abstract

Abstract : Summary: Porencephalic cyst/encephalomalacia is often associated with intractable epilepsy. A limited number of studies reported magnetoencephalography's (MEG's) potential to help construct treatment strategy for epilepsies associated with porencephalic cyst/encephalomalacia. The authors present here simultaneous electroencephalography (EEG) and MEG findings in three adult patients with pediatric-onset epilepsy due to porencephalic cyst/encephalomalacia. There were two types of spikes: one type was detected by MEG only (EEG−/MEG+), and the other detected by both EEG and MEG (EEG+/MEG+). Both types were seen in all three cases. The EEG−/MEG+ spikes all formed tight clusters; in contrast, the majority of EEG+/MEG+ spikes formed loose clusters. These data suggest that MEG may be helpful to better identify spike populations in epilepsy patients with porencephalic cyst/encephalomalacia. If hidden spike populations were to be found by MEG, this information would affect the interpretation of patient's pathophysiology and planning of intracranial electrode placement.