Comparison of Bayesian and regression models in missing enzyme identification. (11th November 2008)

• Record Type: Journal Article
• Authors: Geng, Bo; Zhou, Xiaobo; Hung, Y.S.; Wong, Stephen
• Is Part Of: International journal of bioinformatics research and applications. Volume 4:Number 4(2008)
• Page Start: 363
• Page End: 374
• Publication Date: 2008-11-11
• Subjects: metabolic networks -- network reconstruction -- missing enzymes identification -- regression models -- Bayesian model -- E coli -- bioinformatics -- genomic sequencing; Bioinformatics -- Periodicals; 570.285
• Languages: English
• ISSNs: 1744-5485

Abstract

Computational identification of missing enzymes is important in metabolic network reconstruction. For a metabolic reaction, given a set of candidate enzymes identified by biological evidences, a powerful predictive model is necessary to predict the actual enzyme(s) catalysing the reaction. In this study, we compare Bayesian Method, which is used in previous work, with several regression models. We apply the models to known reactions in E. coli and three other bacteria. It is shown that the proposed regression models obtain favourable performance when compared with the Bayesian method.