Coronary fluorine-18-sodium fluoride uptake is increased in healthy adults with an unfavorable cardiovascular risk profile: results from the CAMONA study. Issue 11 (November 2017)

• Record Type: Journal Article
• Authors: Blomberg, Björn A.; Thomassen, Anders; de Jong, Pim A.; Lam, Marnix G.E.; Diederichsen, Axel C.P.; Olsen, Michael H.; Mickley, Hans; Mali, Willem P.T.M.; Alavi, Abass; Høilund-Carlsen, Poul F.
• Is Part Of: Nuclear medicine communications. Volume 38:Issue 11(2017:Nov.)
• Publication Date: 2017-11
• Subjects: atherosclerosis -- fluorine-18-sodium fluoride -- PET/CT -- vascular calcification; Nuclear medicine -- Periodicals; 616.07575
• DOI: 10.1097/MNM.0000000000000734
• Languages: English
• ISSNs: 0143-3636

Abstract

Abstract : Objective: Coronary artery fluorine-18-sodium fluoride ( 18 F-NaF) uptake reflects coronary artery calcification metabolism and is considered to be an early prognostic marker of coronary heart disease. This study evaluated the relationship between coronary artery 18 F-NaF uptake and cardiovascular risk in healthy adults at low cardiovascular risk. Participants and methods: Study participants underwent blood pressure measurements, blood analyses, and coronary artery 18 F-NaF PET/CT imaging. In addition, the 10-year risk for the development of cardiovascular disease, on the basis of the Framingham Risk Score, was estimated. Multivariable linear regression evaluated the dependence of coronary artery 18 F-NaF uptake on cardiovascular risk factors. Results: We recruited 89 (47 men, 42 women) healthy adults aged 21–75 years. Female sex (0.34 kBq/ml; P =0.009), age (0.16 kBq/ml per SD; P =0.002), and BMI (0.42 kBq/ml per SD; P <0.001) were independent determinants of increased coronary artery 18 F-NaF uptake (adjusted R 2 =0.21; P <0.001). Coronary artery 18 F-NaF uptake increased linearly according to the number of cardiovascular risk factors present ( P <0.001 for a linear trend). The estimated 10-year risk for the development of cardiovascular disease was on average 2.4 times higher in adults with coronary artery 18 F-NaF uptake in the highest quartile compared with those in the lowest quartile of the distribution (8.0 vs. 3.3%, P <0.001). Conclusion: Our findings indicate that coronary artery 18 F-NaF PET/CT imaging is feasible in healthy adults at low cardiovascular risk and that an unfavorable cardiovascular risk profile is associated with a marked increase in coronary artery 18 F-NaF uptake.