Human Semen Quality, Sperm DNA Damage, and the Level of Reproductive Hormones in Relation to Urinary Concentrations of Parabens. Issue 11 (November 2017)

• Record Type: Journal Article
• Authors: Jurewicz, Joanna; Radwan, Michał; Wielgomas, Bartosz; Dziewirska, Emila; Karwacka, Anetta; Klimowska, Anna; Kałużny, Paweł; Radwan, Paweł; Bochenek, Michał; Hanke, Wojciech
• Is Part Of: Journal of occupational and environmental medicine. Volume 59:Issue 11(2017)
• Publication Date: 2017-11
• Subjects: Medicine, Industrial -- Periodicals; Environmental health -- Periodicals; Occupational Medicine -- Periodicals; Environmental Medicine -- Periodicals; Environmental health; Medicine, Industrial; Periodicals; Electronic journals; 616.9803
• DOI: 10.1097/JOM.0000000000001106
• Languages: English
• ISSNs: 1076-2752

Abstract

Abstract : Objective: The aim of this study was to evaluate the association between environmental exposure to parabens and semen quality parameters [main semen parameters, computer-aided semen analysis (CASA parameters], sperm chromatin structure, and the level of reproductive hormones in men [follicle-stimulating hormone (FSH), testosterone, estradiol]. Methods: Urine samples collected from 315 men who attended the infertility clinic for diagnostic purposes with normal semen concentration of 15 to 300 mln/mL were analyzed for five parabens concentrations using a validated gas chromatography ion-tap mass spectrometry method. Participants were interviewed and also provided a semen, saliva, and blood samples. Results: Urinary parabens concentrations were significantly associated with an increase in the percentage of sperm with abnormal morphology, in sperm with high DNA stainability and a decrease in the percentage of motility and testosterone level. Conclusions: This is one of the first study on this topic, so the observation of the relationship between parabens and semen quality warrants further investigation.