Platelet pathophysiology, pharmacology, and function in coronary artery disease. Issue 7 (November 2017)

• Record Type: Journal Article
• Authors: Ibrahim, Homam; Kleiman, Neal S.
• Is Part Of: Coronary artery disease. Volume 28:Issue 7(2017:Nov.)
• Publication Date: 2017-11
• Subjects: antiplatelet drugs -- platelet function testing -- platelets -- thrombosis; Coronary heart disease -- Periodicals; Coronary Disease -- Indexes; Coronary Disease -- Periodicals; 616.123005
• DOI: 10.1097/MCA.0000000000000519
• Languages: English
• ISSNs: 0954-6928

Abstract

Abstract : Platelets play a key role in the pathophysiology of coronary artery disease and acute coronary syndromes. Our understanding of platelet function in thrombus formation has increased considerably, resulting in the development of clinically effective treatment strategies and identification of new targets. An underappreciated platelet function is their contribution toward acute and chronic inflammatory processes including atherogenesis. In this review, we discuss the role of platelets in atherosclerosis and thrombosis, platelet function testing, and the pharmacology of currently available antiplatelet drugs.