Mitochondrial dysfunction in cancer chemoprevention by phytochemicals from dietary and medicinal plants. (December 2017)

• Record Type: Journal Article
• Authors: Sehrawat, Anuradha; Roy, Ruchi; Pore, Subrata K.; Hahm, Eun-Ryeong; Samanta, Suman K.; Singh, Krishna B.; Kim, Su-Hyeong; Singh, Kamayani; Singh, Shivendra V.
• Is Part Of: Seminars in cancer biology. Volume 47(2017)
• Page Start: 147
• Page End: 153
• Publication Date: 2017-12
• Subjects: BITC benzyl isothiocyanate -- Drp1 dynamin-related protein 1 (also known as DNM1L and dynamin 1 like -- ETC electron transport chain -- HNK honokiol -- ITCs isothiocyanates -- OXPHOS oxidative phosphorylation -- PEITC phenethyl isothiocyanate -- ROS reactive oxygen species -- SFN sulforaphane -- WA withaferin A; Phytochemicals -- Mitochondrial dysfunction -- Mitochondrial dynamics -- Electron transport chain -- Chemoprevention; Cancer -- Periodicals; Neoplasms -- Periodicals; Review Literature; Cancer -- Périodiques; Electronic journals; 616.994
• DOI: 10.1016/j.semcancer.2016.11.009
• Languages: English
• ISSNs: 1044-579X

Abstract

Abstract: Cancer chemoprevention, a scientific term coined by Dr. Sporn in the late seventies, implies use of natural or synthetic chemicals to block, delay or reverse carcinogenesis. Phytochemicals derived from edible and medicinal plants have been studied rather extensively for cancer chemoprevention using preclinical models in the past few decades. Nevertheless, some of these agents (e.g., isothiocyanates from cruciferous vegetables like broccoli and watercress) have already entered into clinical investigations. Examples of widely studied and highly promising phytochemicals from edible and medicinal plants include cruciferous vegetable constituents (phenethyl isothiocyanate, benzyl isothiocyanate, and sulforaphane), withaferin A (WA) derived from a medicinal plant ( Withania somnifera ) used heavily in Asia, and an oriental medicine plant component honokiol (HNK). An interesting feature of these structurally-diverse phytochemicals is that they target mitochondria to provoke cancer cell-selective death program. Mechanisms underlying cell death induction by commonly studied phytochemicals have been discussed rather extensively and thus are not covered in this review article. Instead, the primary focus of this perspective is to discuss experimental evidence pointing to mitochondrial dysfunction in cancer chemoprevention by promising phytochemicals.