A pilot study of a nurse-delivered cognitive behavioral therapy intervention (Ziphamandla) for adherence and depression in HIV in South Africa. (May 2018)

• Record Type: Journal Article
• Authors: Andersen, Lena S; Magidson, Jessica F; O'Cleirigh, Conall; Remmert, Jessica E; Kagee, Ashraf; Leaver, Matthew; Stein, Dan J; Safren, Steven A; Joska, John
• Is Part Of: Journal of health psychology. Volume 23:Number 6(2018)
• Page Start: 776
• Page End: 787
• Publication Date: 2018-05
• Subjects: adherence -- cognitive behavioral therapy -- depression -- HIV -- low- and middle-income countries -- South Africa -- task-sharing; Clinical health psychology -- Periodicals; 613.019
• DOI: 10.1177/1359105316643375
• Languages: English
• ISSNs: 1359-1053

Abstract

Depression is prevalent among people living with HIV in South Africa and interferes with adherence to antiretroviral therapy. This study evaluated a nurse-delivered, cognitive behavioral therapy intervention for adherence and depression among antiretroviral therapy users with depression in South Africa ( n = 14). Primary outcomes were depression, antiretroviral therapy adherence, feasibility, and acceptability. Findings support robust improvements in mood through a 3-month follow up. Antiretroviral therapy adherence was maintained during the intervention period. Participant retention supports acceptability; however, modest provider fidelity despite intensive supervision warrants additional attention to feasibility. Future effectiveness research is needed to evaluate this nurse-delivered cognitive behavioral therapy intervention for adherence and depression in this context.