An Electrophilic Reagent for the Direct Introduction of the SCF2PO(OEt)2 Group to Molecules. Issue 43 (26th September 2016) - Xiong, Heng‐Ying
Abstract: An unprecedented electrophilic difluoromethylthiolating reagent (MesNHSCF2 PO(OEt)2 ) was designed. Under mild and metal‐free conditions, this new reagent reacted with various nucleophiles, thus offering an efficient and operationally simple tool for the construction of C−SCF2 PO(OR)2, N−SCF2 PO(OR)2, and S−SCF2 PO(OR)2 bonds. Finally, thanks to this new methodology, the synthesis of the non‐stereoidal anti‐inflammatory diflumidone was achieved. Abstract : Tool up : A new electrophilic difluoromethylthiolating reagent (MesNHSCF2 PO(OEt)2 ) was treated with various nucleophiles under mild and metal‐free conditions, thus offering an efficient and operationally simple tool for the construction of C−SCF2 PO(OR)2, N−SCF2 PO(OR)2, and S−SCF2 PO(OR)2 bonds. The versatility of this method was illustrated through the synthesis of the non‐stereoidal anti‐inflammatory compound diflumidone.