Front Cover: Hydrophobic Magnetic Nanoparticle Assisted One‐Pot Liquid‐Phase Peptide Synthesis (Eur. J. Org. Chem. 40/2017). Issue 40 (10th October 2017)

• Record Type: Journal Article
• Authors: Okada, Yohei; Asama, Hitomi; Wakamatsu, Hiroki; Chiba, Kazuhiro; Kamiya, Hidehiro
• Is Part Of: European journal of organic chemistry. Issue 40(2017)
• Page Start: 5942
• Page End: 5942
• Publication Date: 2017-10-10
• Subjects: Chemistry, Organic -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1002/ejoc.201701387
• Languages: English
• ISSNs: 1434-193X

Abstract

Abstract : The Front Cover shows an experimental procedure for the hydrophobic magnetic nanoparticle assisted one‐pot liquid‐phase peptide synthesis using a soluble tag method. Both couplings and deprotections of the tagged substrate are effectively carried out, even in the presence of the magnetic nanoparticles in a less‐polar solvent. After reaction completion, a polar solvent is added to the reaction mixture to precipitate the desired tagged peptide with the magnetic nanoparticles. The thus formed magnetic precipitate is readily collected by a magnet, enabling an effective one‐pot procedure. More information can be found in theCommunication by Y. Okada et al.