A Highly Active Manganese Catalyst for Enantioselective Ketone and Ester Hydrogenation. Issue 21 (20th April 2017)

• Record Type: Journal Article
• Authors: Widegren, Magnus B.; Harkness, Gavin J.; Slawin, Alexandra M. Z.; Cordes, David B.; Clarke, Matthew L.
• Is Part Of: Angewandte Chemie international edition. Volume 56:Issue 21(2017)
• Page Start: 5825
• Page End: 5828
• Publication Date: 2017-04-20
• Subjects: enantioselective catalysis -- ester hydrogenation -- ferrocene -- manganese -- reduction; Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201702406
• Languages: English
• ISSNs: 1433-7851

Abstract

Abstract: A new hydrogenation catalyst based on a manganese complex of a chiral P, N, N ligand has been found to be especially active for the hydrogenation of esters down to 0.1 mol % catalyst loading, and gives up to 97 % ee in the hydrogenation of pro‐chiral deactivated ketones at 30–50 °C. Abstract : Non‐precious metal for valuable catalysis : A new manganese catalyst for enantioselective ketone hydrogenation has been developed (see scheme). This catalyst also hydrogenates esters at low catalyst loadings for an earth‐abundant metal system.