Upregulation of an Artificial Zymogen by Proteolysis. Issue 38 (16th August 2016) - Liu, Zhe
Abstract: Regulation of enzymatic activity is vital to living organisms. Here, we report the development and the genetic optimization of an artificial zymogen requiring the action of a natural protease to upregulate its latent asymmetric transfer hydrogenase activity. Abstract : Cut it on ! An artificial zymogen with latent asymmetric transfer hydrogenase activity was developed and genetically optimized. Its upregulation by a natural protease is demonstrated (see picture; Sav=streptavidin).