Modulating NAD+ metabolism, from bench to bedside. (7th August 2017)

• Record Type: Journal Article
• Authors: Katsyuba, Elena; Auwerx, Johan
• Is Part Of: EMBO journal. Volume 36:Number 18(2017)
• Page Start: 2670
• Page End: 2683
• Publication Date: 2017-08-07
• Subjects: aging -- metabolic disorders -- neurodegeneration -- nicotinamide adenine dinucleotide -- poly ADP‐ribose polymerase; Molecular biology -- Periodicals; 572.805
• DOI: 10.15252/embj.201797135
• Languages: English
• ISSNs: 0261-4189

Abstract

Abstract: Discovered in the beginning of the 20 th century, nicotinamide adenine dinucleotide (NAD + ) has evolved from a simple oxidoreductase cofactor to being an essential cosubstrate for a wide range of regulatory proteins that include the sirtuin family of NAD + ‐dependent protein deacylases, widely recognized regulators of metabolic function and longevity. Altered NAD + metabolism is associated with aging and many pathological conditions, such as metabolic diseases and disorders of the muscular and neuronal systems. Conversely, increased NAD + levels have shown to be beneficial in a broad spectrum of diseases. Here, we review the fundamental aspects of NAD + biochemistry and metabolism and discuss how boosting NAD + content can help ameliorate mitochondrial homeostasis and as such improve healthspan and lifespan. Abstract : As part of our focus series on metabolism, this review discusses the physiological role of NAD + and the potential therapeutic effects of increasing NAD + levels.