Vascular and metabolic comorbidities in open‐angle glaucoma with low‐ and high‐teen intraocular pressure: a cross‐sectional study from South Korea. Issue 7 (5th July 2017)

• Record Type: Journal Article
• Authors: Lee, Si Hyung; Kim, Gyu Ah; Lee, Wonseok; Bae, Hyoung Won; Seong, Gong Je; Kim, Chan Yun
• Is Part Of: Acta ophthalmologica. Volume 95:Issue 7(2017)
• Page Start: e564
• Page End: e574
• Publication Date: 2017-07-05
• Subjects: diabetes -- hyperlipidemia -- hypertension -- metabolic syndrome -- normal‐tension glaucoma; Ophthalmology -- Periodicals; 617.7005
• DOI: 10.1111/aos.13487
• Languages: English
• ISSNs: 1755-375X

Abstract

Abstract: Purpose: To assess the associations between vascular and metabolic comorbidities and the prevalence of open‐angle glaucoma (OAG) with low‐teen and high‐teen intraocular pressure (IOP) in Korea. Methods: Cross‐sectional data from the Korean National Health and Nutrition Examination Survey from 2008 to 2012 were analysed. Participants diagnosed with OAG with normal IOP were further classified into low‐teen IOP (IOP ≤ 15 mmHg) and high‐teen IOP (15 mmHg < IOP ≤ 21 mmHg) groups. Using multiple logistic regression analyses, the associations between vascular and metabolic comorbidities and the prevalence of glaucoma were investigated for the low‐ and high‐teen IOP groups. Results: The prevalences of hypertension, hyperlipidemia, ischaemic heart disease, stroke and metabolic syndrome were significantly higher among subjects with low‐teen OAG compared with normal subjects, while only the prevalences of hypertension and stroke were higher among subjects with high‐teen OAG compared with normal subjects. In multivariate logistic regression models adjusted for confounding factors, low‐teen OAG was significantly associated with hypertension (OR, 1.68; 95% CI, 1.30–2.18), hyperlipidemia (OR, 1.49; 95% CI, 1.07–2.08), ischaemic heart disease (OR, 1.83; 95% CI, 1.07–3.11), stroke (OR, 1.91; 95% CI, 1.12–3.25) and metabolic syndrome (OR, 1.46; 95% CI, 1.12–1.90). High‐teen OAG was only associated with stroke (OR, 2.58; 95% CI, 1.20–5.53). Conclusion: Various vascular and metabolic comorbidities were significantly associated with low‐teen OAG, but not with high‐teen OAG. These data support the hypothesis that vascular factors play a more significant role in the pathogenesis of OAG with low‐teen baseline IOP.