Polybenzimidazole‐Triphenylphosphene‐Catalyzed One‐Pot Synthesis and Evaluation of Dihydropyridine Derivative as Antibiotics and Antifungals. Issue 25 (1st September 2017)

• Record Type: Journal Article
• Authors: Perumal, Muthuraja; Sengodu, Prakash; Venkatesan, Sethuraman; Perumal, Sathiaseelan; Antony, Susaimanickam; Paramsivam, Manisankar
• Is Part Of: ChemistrySelect. Volume 2:Issue 25(2017)
• Page Start: 7489
• Page End: 7496
• Publication Date: 2017-09-01
• Subjects: Antimicrobial activity -- Dihydropyridines -- Green synthesis -- One- pot synthesis multicomponent -- Polymer catalyst; Chemistry -- Periodicals; 540.5
• DOI: 10.1002/slct.201700918
• Languages: English
• ISSNs: 2365-6549

Abstract

Abstract: Dihydropyridines derivative have been synthesized by one‐pot multicomponent cyclocondensation reaction using PBI‐PPh3 catalyst. This catalyst is characterized by the solid state of 13 C‐NMR, 15 N‐NMR, and 31 P‐NMR spectrum, FT‐IR, cyclic voltammetry, and XRD analysis. The selection of catalyst is quite interesting because of its affordability, toxic free nature and high stability. Functional groups of all dihydropyridines confirms by H 1 ‐NMR and FTIR spectra. Synthesized compounds show exceptional yields of 96–99 %. Synthesized compounds has evaluated for their invitro antibacterial activity against B. subtilis, and P. vulgaris (ATCC 49565) and C. albicans (ATCC 90028). Synthesized dihydropyridines showed promising antibacterial and antifungal activities, in particularly, ethyl‐4‐(4‐methylphenyl)‐2, 7, 7‐trimethyl‐5‐oxo‐1, 4, 5, 6, 7, 8‐hexadihydropyridine‐3‐carboxylate are exhibiting a higher inhibition zone of 66.7 % against bacteria. Our method may help to drug chemists for design more interesting, useful, and sustainable reactions in the near future. Abstract : A solvent‐free multicomponent reaction for the synthesis of dihydropyridines has been developed from aldehydes, ammonia acetate, cyclohexanedione, and ethyl acetoacetate by employing efficient PBI‐PPh3 catalyst. This catalyst is characterized by the solid state of 13 C‐NMR, 15 N‐NMR, and 31 P‐NMR spectrum, FT‐IR, cyclic voltammetry, and XRD analysis. Synthesized compounds show exceptional yields of 96–99 %. Synthesized compounds has evaluated for their invitro antibacterial and antifungal activity.