Developmental gene expression in the mouse clarifies the organization of the claustrum and related endopiriform nuclei. Issue 6 (23rd May 2016)

• Record Type: Journal Article
• Authors: Watson, Charles; Puelles, Luis
• Is Part Of: Journal of comparative neurology. Volume 525:Issue 6(2017)
• Page Start: 1499
• Page End: 1508
• Publication Date: 2016-05-23
• Subjects: claustrum -- dorsal endopiriform nucleus -- ventral endopiriform nucleus -- lateral pallium -- insular cortex -- ventral pallium -- Nr4a2 expression; Comparative neurobiology -- Periodicals; Neurology -- Periodicals; 616
• DOI: 10.1002/cne.24034
• Languages: English
• ISSNs: 0021-9967

Abstract

ABSTRACT: Studies on gene expression in the developing claustrum of the mouse have clarified the relationships and identity of the claustrum proper and related endopiriform nuclei. The cells of the claustrum primordium express Nr4a2 ; they are formed in combination with the Nr4a2‐ labeled subplate cells in the lateral pallium at the site of the future insular cortex. The insular cortex cells, which are born later and which are Nr4a2 ‐negative, migrate through the claustrum toward the pial surface to form layers (2–6a) of the insular cortex. The claustrum is made up of distinct deep (subplate‐like) and superficial (principal) parts. The cells of the dorsal endopiriform nucleus (which are also Nr4a2‐ positive) are formed in the deep part of the claustrum primordium in the lateral pallium, but they migrate ventrally to reach the ventral pallium deep to the piriform cortex at E14.5 in the mouse. On the other hand, the ventral endopiriform nucleus is formed by radially migrating Nr4a2 ‐negative cells in the ventral pallium; it is therefore developmentally distinct from the Nr4a2‐ postive dorsal endopiriform nucleus, which is a lateral pallial derivative. J. Comp. Neurol. 525:1499–1508, 2017. © 2016 Wiley Periodicals, Inc. Abstract : The cells of the claustrum primordium in the lateral pallium express Nr4a2 . The insular cortex cells, which are born later and which are Nr4a2 ‐negative, migrate through the claustrum toward the pial surface. The Nr4a2‐ positive cells of the dorsal endopiriform nucleus (DEn) are formed in the deep part of the claustrum primordium and migrate ventrally to reach the ventral pallium deep to the piriform cortex.