Potential involvement of NET polymorphism in serotonin/norepinephrine reuptake inhibitor response in panic disorder. (18th May 2016)

• Record Type: Journal Article
• Authors: Park, Hae Jeong; Kim, Su Kang; Kang, Won Sub; Kim, Young Jong; Cho, Ah Rang; Park, Jin Kyung
• Is Part Of: Nordic journal of psychiatry. Volume 70:Number 4(2016)
• Page Start: 314
• Page End: 317
• Publication Date: 2016-05-18
• Subjects: Norepinephrine transporter -- panic disorder -- selective serotonin reuptake inhibitor -- serotonin transporter -- serotonin/norepinephrine reuptake inhibitor; Psychopharmacology -- Periodicals; Psychotherapy -- Periodicals; Psychiatry -- Periodicals; Psychiatry -- Scandinavia -- Periodicals; 616.89
• DOI: 10.3109/08039488.2015.1089321
• Languages: English
• ISSNs: 0803-9488

Abstract

Abstract: Background : This is a pilot study assessing the impact of polymorphisms of serotonin transporter ( 5-HTT ; 5-HTTLPR (S/L)) and norepinephrine transporter ( NET ; rs2242446 (T/C)) genes on selective serotonin reuptake inhibitors (SSRIs) and serotonin/norepinephrine reuptake inhibitors (SNRIs) response in Korean panic disorder (PD) patients. Methods : PD patients were treated with SSRI ( n = 18) or SNRI ( n = 6) for 4 weeks. Panic Disorder Severity Scale (PDSS) was rated to evaluate the treatment response. Wilcoxon signed-rank test was used to compare PDSS scores before and after medication (SSRI or SNRI) as well as to compare those according to genotypes. Mann–Whitney U test was used to compare those between the two groups (SSRI or SNRI). Results : Both SSRI and SNRI treatments for 4 weeks significantly reduced PDSS scores. We assessed the impact of rs2242446 on this effect of SSRI and SNRI. The scores were significantly decreased after 4 weeks in the SSRI-treated group regardless of genotypes of rs2242446, whereas they were significantly decreased in the SNRI-treated group with only non-C carrier (TT) of rs2242446. On 5-HTTLPR we could not analyse because 22 patients had SS genotype. Conclusions : These results suggest that NET polymorphism may affect the SNRI response in Korean PD patients.